Dihydrofolate Reductase is involved in many reaction pathways. Links to individual pathways and an example pathway involving didhydrofolate reductase and folate A are shown below. Note that dihydrofolate reductase is specified by the numbers 1.5 1.3.

EC Primary Enzyme Name: Dihydrofolate reductase
EC Synonym Enzyme Names: Tetrahydrofolate dehydrogenase
Comment: Tetrahydrofolate is a C1 donor involved in many metabolic processes. It is an essential step for de novo glycine and purine synthesis, DNA precursor synthesis and for conversion of dUMP to dTMP.

Reactions in which Dihydrolate Reductase Participates:

• dihydrofolate reductase : folA (Escherichia coli K-12)
• dihydrofolate reductase : ydgB (Escherichia coli K-12)
• dihydrofolate reductase/thymidylate synthase (Pisum sativum)
• dihydrofolate reductase/thymidylate synthase : THY-2 (Arabidopsis thaliana col)
• dihydrofolate reductase/thymidylate synthase : THY-1 (Arabidopsis thaliana col)
• dihydrofoalate reductase/thymidylate synthase : DHFR-TS (Glycine max)
• dihydrofolate reductase : folA (Mycoplasma pneumoniae M129)
• dihydrofolate reductase : dyrA (Thermotoga maritima)